Dendritic Cell Vaccination group

Dendritic Cell (DC) therapy represents a promising immunotherapeutic approach for the treatment of cancer. The beauty of DC therapy is that it exploits the body’s own immune system to fight cancer. We were amongst the first (since 1997) investigating the potency of this approach, where DC were isolated or grown from immune cells isolated from the blood of a cancer patient. Within specialized cleanrooms, personalized DC vaccines are prepared by activating DC and loading them with tumor antigens. Subsequently, patients are vaccinated. For more details on the DC vaccination procedure see this movie. So far, we have mainly focused on melanoma, a cancer of the pigmented cells of the skin. We have treated more than 350 patients until now and observed that DC vaccination is well tolerated with minimal side effects. In some patients we have seen remarkable and long lasting remissions. We constantly improve our vaccines to reach even better clinical results.

Team members clinical trials:
Technicians: Annemiek de Boer, Kevin Bos, Tjitske Duiveman-de Boer, Tom van Oorschot, Jeanette Pots, Mandy van de Rakt, Nicole Scharenborg
Physicians: Jeroen Creemers, Harm Westdorp
Trial manager, Research nurse: Simone Hins-de Bree
Proces operator: Gerty Schreibelt

Tom van Oorschot

Since 2013 I am joining the department of Tumor Immunology and I am part of the ‘patient group’. Together with my colleagues we perform clinical trials with DC vaccinations and particles.

Besides these tasks I am responsible for the flowcytometers on our department and recently I started a project for the coming 3 years with Friesland Campina.

Outside the lab I love to go on adventure preferably with a race or mountainbike.   

Jeanette Pots

Jeanette Pots obtained her BSc degree in Biology and Medical Laboratory research at Saxion University of Applied Sciences, Enschede and her MSc degree in Biology at Radboud University Nijmegen in 2006. During her master internship, she became fascinated by immunology and cancer. During her first job as research technician at the department of Experimental Haematology, Leiden University Medical Center, she worked on a project focusing on regulatory T cells and acute myeloid leukaemia. In 2009, she joined the department of Tumor Immunology in the group of Prof. Dr. Jolanda de Vries, and combined her GMP experience with her interest for dendritic cell therapy in cancer patients. Currently, she works on projects focusing on experimental treatments with dendritic cells or immunomodulatory nanomedicines. Her goal has always been a job where she could combine doing research with training students. Therefore, she took the opportunity, after completing her post-graduate course Didactics in higher education at HAN, to teach and support bachelor students biomedical sciences and medicine at the Radboudumc in getting a solid basis for their future careers. In her spare time, Jeanette enjoys playing volleyball, spending time with family and friends and enjoying nature and traveling.

Mandy van de Rakt

After my study HLO-microbiology, I worked at ErasmusMC and UMCUtrecht. In 2004 I started working at TIL. I’m working as a technician in the patient group. We’re working in the cleanroom to make DC-vaccines for patients. In addition to being a technician I am also a quality assurance engineer and PAM.

Outside of the lab I like to work in our garden, vegetable garden and take care of our ponies. And to keep in shape I run in our green environment.

Former Team members:
Carlijn Popelier (technician)